ДOCBIДЛIКУBAHHЯ BУЛЬBOBAГIHITIB ПОЄДНАНИХ З ДИСПЛАЗІЯМИ ШИЙКИ МАТКИ.

To study the ciinicai and iaboratory efficacy and safety of vaginai use of the Lomeksin for the treatment of vuivovaginitis caused by Candida and microbiaiassociations in conjunction with squamous cervicai dyspiasia there were examined and treated 5O patients aged 18 to З? years, mean age was 2З,9±5,4 years. Vuivoginitis, caused by fungi, vegetating in the form of yeast, budding fungi and in the form of myceiium, diagnosed in 1З.8 % microscopy of vaginai smears . However, oniy in 5O.O %of patients we diagnosed opportunistic fiora in the form of Gram-positive coccus, and the compiete absence of Doderiein baciiiusat54.O % and their faiiure in44.O % of patients. In our opinion, suchmicrobiocenosis of vagina preciudes therapeutic purposes preparations containing antibiotics. Ciinicai and iaboratory efficacy of the Lomeksin for vuivoginitis treatment caused by yeast fungi in vegetative forms, in conjunction with opportunistic coccai fiora was 94.O %. High efficacy, toierabiiity, ease of use, avaiiabiiity of dosage forms for simuitaneous treatment of sexuai partners and the absence of side effects can be recommended for wide use in ciinicai practice.С целью изучения клинической и лабораторной эффективности и безопасности вагинального применения препарата Ломексин для лечения вульвовагинитов, обусловленных кандидами и микробными ассоциациями в сочетании с плоскоклеточной дисплазией шейки матки обследовано и пролечено 5O больных в возрасте от 18 до З? лет, средний возраст составил 2З,9±5,4 лет. Byльвoгиниты, обусловленные грибами, вегетирующими в форме дрожжей , грибами почкующимися и в форме мицелия, диагностируются в 1З,8 % микроскопий влагалищных мазков. При этом лишьу 5O,O % больных диагностируется условно-патогенная флора ввиде грамположительных кокков, а полное отсутствие палочек Додерлейна у 54,O % и их недостаточность у 44,O % больных. По нашему мнению, подобный микробиоценоз влагалища исключает возможность применения с лечебной целью препаратов, содержащих антибиотики. Клиническая и лабораторная эффективность применения препарата Ломексин для лечениявульвогинитив, обусловленных дрожжевыми грибами в вегетирующих формах, в комплексе с условно-патогенной кокковой флорой составляла 94,O %. Bыcoкaя эффективность препарата, хорошая переносимость, удобство применения, наличие лекарственных форм для одновременного лечения половых партнеров и отсутствие побочных эффектов позволяют рекомендовать его для широкого использования в клинической практике. З метою вивчення клінічної та лабораторної ефективності і безпечності вагінального застосування препарату Ломексин для лікування вульвовагінітів, обумовлених кандидами і мікробними асоціаціями в сполученні з плоскоклітинними дісплазіями шийки матки обстежено іпроліковано 5O хворих віком від 18 до З? років, середній вік склав 2З,9±5,4 років. Byльвoгiнiти, які обумовлені грибами, що вегетуютьу формі дріжджів, грибами, що брунькуються, й у формі міцелію, діагностуються у 1З,8 % мікроскопій вагінальних мазків. При цьому тільки у 5O,O % хворих діагностується умовно-патогенна флора у вигляді грампозитивних коків, а повна відсутність паличок Додерлейна у 54,O % і їхня недостатність у 44,O % хворих. На нашу думку, подібний мікробіоценоз піхви виключає можливість застосування з лікувальною метою препаратів, які містять антибіотики. Клінічна і лабораторна ефективність застосування препарату Ломексин для лікування вульвогінітів, обумовлених дріжджовими грибами у формах, що вегетують, в комплексі з умовно-патогенною коковою флорою становила 94,O %. Bиcoкa ефективність препарату, добра переносність,зручність застосування, наявність лікарських форм для одночасного лікування статевих партнерів та відсутність побічних ефектів дозволяють рекомендувати його для широкого використання у клінічній практиці

Media justice: Madeleine McCann, intermediatization and "trial by media" in the British press

Three-year-old Madeleine McCann disappeared on 3 May 2007 from a holiday apartment in Portugal. Over five years and multiple investigations that failed to solve this abducted child case, Madeleine and her parents were subject to a process of relentless ‘intermediatization’. Across 24–7 news coverage, websites, documentaries, films, YouTube videos, books, magazines, music and artworks, Madeleine was a mediagenic image of innocence and a lucrative story. In contrast to Madeleine’s media sacralization, the representation of her parents, Kate and Gerry McCann, fluctuated between periods of vociferous support and prolonged and libellous ‘trial by media’. This article analyses how the global intermediatization of the ‘Maddie Mystery’ fed into and fuelled the ‘trial by media’ of Kate and Gerry McCann in the UK press. Our theorization of ‘trial by media’ is developed and refined through considering its legal limitations in an era of ‘attack journalism’ and unprecedented official UK inquiries into press misconduct and criminality

Efficacy of once daily darunavir/ritonavir 800/100 mg in PI/r-experienced HIV-1 infected patients with suppressed HIV-1 replication: the RADAR study

International audiencen.

Liver Stiffness Measurement With FibroScan: Use the Right Probe in the Right Conditions!

INTRODUCTION: FibroScan\u27s M and XL probes give significantly different results, which could lead to misevaluation of liver fibrosis if the correct probe is not chosen. According to the manufacturer, the M probe should be used when the skin-liver capsule distance (SCD) is <25 mm, and the XL probe should be used when SCD is ≥25 mm. We aimed at validating this recommendation and defining the conditions of use for FibroScan probes in clinical practice. METHODS: Four hundred thirty-nine patients with biopsy-proven chronic liver disease were included. Of them, 382 had successful examinations with both M and XL probes. Advanced fibrosis was defined as Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) F ≥3 or Metavir F ≥2. RESULTS: In a same patient, XL probe results were significantly lower than M probe results: 7.9 (5.6-11.7) vs 9.5 (6.7-14.6) kPa, respectively (P < 0.001). After matching for age, sex, liver fibrosis, and serum transaminases, M probe results in patients with SCD <25 mm and XL probe results in those with SCD ≥25 mm did not significantly differ: 8.8 (6.0-12.0) vs 9.1 (6.7-12.8) kPa, respectively (P = 0.175). Of note, 81.4% of patients with body mass index (BMI) <32 kg/m had SCD <25 mm, and 77.7% of patients with BMI ≥32 kg/m had SCD ≥25 mm. A practical algorithm using BMI first and then the FibroScan Automatic Probe Selection tool was proposed to help physicians accurately choose which probe to use in clinical practice. CONCLUSIONS: There is no significant difference in results between M and XL probes when they are used in the right conditions. In clinical practice, the probe should be selected according to the BMI and the Automatic Probe Selection tool

Estimating the Cost of No-Shows and Evaluating the Effects of Mitigation Strategies

To measure the cost of non-attendance (“no-shows”) and benefit of overbooking and interventions to reduce no-shows for an outpatient endoscopy suite

Real-time smart and standalone vision/IMU navigation sensor

In this paper, we present a smart, standalone, multi-platform stereo vision/IMU-based navigation system, providing ego-motion estimation. The real-time visual odometry algorithm is run on a nano ITX single-board computer (SBC) of 1.9 GHz CPU and 16-core GPU. High-resolution stereo images of 1.2 megapixel provide high-quality data. Tracking of up to 750 features is made possible at 5 fps thanks to a minimal, but efficient, features detection–stereo matching–feature tracking scheme runs on the GPU. Furthermore, the feature tracking algorithm benefits from assistance of a 100 Hz IMU whose accelerometer and gyroscope data provide inertial features prediction enhancing execution speed and tracking efficiency. In a space mission context, we demonstrate robustness and accuracy of the real-time generated 6-degrees-of-freedom trajectories from our visual odometry algorithm. Performance evaluations are comparable to ground truth measurements from an external motion capture system

CrashEd – A live immersive, learning experience embedding STEM subjects in a realistic, interactive crime scene

Interactive experiences are rapidly becoming popular via the surge of ‘escape rooms’; part game and part theatre, the ‘escape’ experience is exploding globally, having gone from zero offered at the outset of 2010 to at least 2800 different experiences available worldwide today. CrashEd is an interactive learning experience that parallels many of the attractions of an escape room – it incorporates a staged, realistic ‘crime scene’ and invites participants to work together to gather forensic evidence and question a witness in order to solve a crime, all whilst competing against a ticking clock. An animation can enhance reality and engage with cognitive processes to help learning; in CrashEd, it is the last piece of the jigsaw that consolidates the students’ incremental acquisition of knowledge to tie together the pieces of evidence, identify a suspect and ultimately solve the crime. This article presents the background to CrashEd and an overview of how a timely placed animation at the end of an educational experience can enhance learning. The lessons learned, from delivering bespoke versions of the experience to different demographic groups, are discussed. The article will consider the successes and challenges raised by the collaborative project, future developments and potential wider implications of the development of CrashEd

Local and global interactions in an evolutionary resource game

Conditions for the emergence of cooperation in a spatial common-pool resource game are studied. This combines in a unique way local and global interactions. A fixed number of harvesters are located on a spatial grid. Harvesters choose among three strategies: defection, cooperation, and enforcement. Individual payoffs are affected by both global factors, namely, aggregate harvest and resource stock level, and local factors, such as the imposition of sanctions on neighbors by enforcers. The evolution of strategies in the population is driven by social learning through imitation, based on local interaction or locally available information. Numerous types of equilibria exist in these settings. An important new finding is that clusters of cooperators and enforcers can survive among large groups of defectors. We discuss how the results contrast with the non-spatial, but otherwise similar, game of Sethi and Somanathan (American Economic Review 86(4):766–789, 1996)